Dissertation titled „The Interdependency of Management of Brand and Sustainability of Cross-Border Tourist Destination“ assesses the author's model by testing the connections and relationships between the observed variables „Management of Brand of Cross-Border Tourist Destination“ and „Sustainable Tourism Development“ through intervening variables „Cultural Sustainability – Cultural Characteristics“, „Cultural Sustainability – Intercultural Understanding and Tolerance“, „Environmental Sustainability – Environmental Awareness“ and „Political Sustainability – Involvement in Development Processes in Tourism“. In the theoretical part of the paper, systemized and analyzed are the elements of the concept of tourist destination, cross-border tourist destination and brand in tourism. The theoretical aspect of sustainable tourism development has also been analyzed in detail. Based on the operationalization of the observed variables in the paper, a conceptual research model was created. Testing the main hypothesis and four auxiliary ones was conducted on a sample of 151 respondents by using multivariate analysis, namely the factor analysis and correlation analysis based on the Pearson coefficient of linear correlation. The default model was empirically tested through the current picture of the situation in the border areas of the Republic of Croatia and the Republic of Slovenia. The respondents are residents of the border areas of the Republic of Croatia and the Republic of Slovenia who are employed in tourism. The research results confirm the efficiency of the shaped model. Such presented fundamental elements of the model will serve tourism stakeholders of the existing, but also, potential cross-border tourism destinations in the branding process according to the principles of sustainable tourism development. Proven were the directions and intensity of the connections between the observed variables. It was empirically determined the statistically significant moderately positive correlation between the „Brand Management of the Cross-Border Tourism Destination“ and the „Sustainable Tourism Development“. Defined and typologized were links of brand management of cross-border tourism destinations in the context of aspirations of the sustainable tourism development. It presents how individual and joint tourism products based on resource determinants of border areas present an important prerequisite for the formation of the brand of cross-border tourism destination. It was empirically proven the relevant potential of tourism brand of cross-border destination based on resource modifiers of border areas in the function of sustainable tourism development. The paper gives, not only the benefits of branding of the cross-border tourism destinations by a common brand, but also limitations while implementing the process. The conducted research, as well as the presented results are the adequate foothold for future research in the field of management of the brand of cross-border tourism destination and sustainable tourism development. Pragmatic guidelines based on the research results present usable basis for strategic decision making of stakeholders in the management of the brand of cross-border tourism destination.