In early 2020, the world was hit by a pandemic of the Covid 19 virus. In addition to the blows to health, the pandemic has dealt enormous blows to economies and thus to tourism. The aim of this paper was to investigate the impact of the new pandemic on the hotel business and the possibility of adapting the hotel business in a pandemic. The theoretical part deals with the structure and composition of accommodation capacities in the Republic of Croatia. The results of hotel business at the level of regions and the entire Republic of Croatia in the period of the 2018 season and the record year 2019 were also processed. Then the obtained figures were compared with the business in the first year of the 2020 pandemic and it was clear that there was a huge decline in all business indicators and that adjustments are needed to achieve stabilization and later growth in business. Concrete actions and issues should have been observed on a case study example. Thus, in the empirical part of the paper, the analysis of the work (business) of the Salona Palace Hotel was performed in the same way as in the theoretical part. It was found that the Salona Palace hotel also had an extremely high rate of decline in key business indicators, but this rate was still slightly lower than in the rest of the Republic of Croatia and thus in the rest of Dalmatia. The hotel faced many challenges and had burning problems on several sides, but timely and good decisions of the management managed to achieve some results that in the new situation, by the hotel management, were considered satisfactory. Furthermore, it was found that in 2020 there was a change in the structure of guests by country of origin (left without the Asian market due to the interruption of air traffic) and there was a growth of domestic guests of 12%. With all that, there was a drop in the average price.