The research conducted in this paper analyzes the relationship between liquidity and profitability in 2015 on a sample of 40 large companies from four different industries, manufacturing, construction, wholesale and retail and information and communication industries. To be able to conduct a research on this topic, it was necessary first calculate the required indicators. In this case, the coefficient of liquidity and working capital as indicators of liquidity and return on assets (ROA) and return on equity (ROE) as indicators of profitability. The data required for the calculation of the indicators are presented in the statement of financial position and profit and loss account. Statistical analysis was performed by computed regression analysis, Pearson correlation coefficient and Spearman correlation coefficient. When testing hypothesis H1.1. it was found that there was no statistically significant correlation between the liquidity and assets return (ROA) coefficient. Also, when testing hypothesis H1.2., it was found that there is no statistically significant association between working capital and ROE. In the end, we can conclude that it rejects the initial hypothesis about the existence of positive links between liquidity and profitability indicators.