In this final paper, the risks of occupational diseases and ways of risk management in the Republic of Croatia are investigated. The analysis established that middle-aged and elderly people are most often affected in the manufacturing industry, agriculture, forestry and mining, as well as health care and social care workers. The ISO 31000 standard provides generic guidelines for risk management, but at the same time, it does not promote uniform risk management in all organizations. When compiling and implementing a risk management plan, it is necessary to take into account all elements of the business. Also, the method of interviews was used to investigate the impact of occupational diseases in health care on the example of a family medicine practice. Potential occupational diseases in health care and their negative impact on health care staff were analyzed. Occupational diseases in healthcare are rarely proven, and in the case of proof, due to the overload of doctors, they have no one to leave their patients to. Nearly 50 percent of occupational diseases of health professionals are classified as biological factors, and the most common disease is related to infectious diseases. The problem of medical staff is also manifested through frequent sitting, repeating identical actions, skin hypersensitivity, various allergies and respiratory diseases. In order to reduce occupational diseases, medical staff adheres to the measures prescribed by the internal procedure. Frequent disinfection of hands, wearing protective clothing, sterilizing work tools, performing short-term exercises, are just some of the ways to prevent the occurrence of occupational diseases.